PERP Antibody

Blue Ice

Predicted: 21kD
Observed: 21 kD

PERP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Trial Size, IAV

11528520

Human PERP has one isoform (193aa, 21kD). Mouse PERP has one isoform (193aa, 21.6kD) and Rat PERP also has one isoform (193aa, 21.6kD). 2451 can detect human, mouse and rat.

PRS-1202-0.1mg

1 mg/mL

WB: 1-2 μ g/mL; ICC: 10 μ g/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Anti-PERP antibody (2451) was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human PERP.

The immunogen is located within the last 50 amino acids of PERP.

PERP, TP53 apoptosis effector

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.