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TCCR Antibody

TCCR Antibody

Item no.	PRS-2481-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Quantity options	0.02 mg 0.1 mg
Category	Neuroscience Neuroinflammation Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS and de Sauvage FJ. Development of Th1-type immune responses requires the type I cytokine receptor TCCR Nature 2000;407(6806):916-920 Sprecher,C.A., Grant,F.J., Baumgartner,J.W., Presnell,S.R., Schrader,S.K., Yamagiwa,T., Whitmore,T.E., O'Hara,P.J. and Foster,D.F. Cloning and characterization of a novel class I cytokine receptor Biochem. Biophys. Res. Commun. 1998;246(1):82-90
NCBI	IL27RA
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	TCCR Antibody: CRL1,TCCR,WSX1,IL27R,IL-27RA,zcytor1,CRL1,UNQ296/PRO336,Interleukin-27 receptor subunit alpha,Cytokine receptor WSX-1,IL-27 receptor subunit alpha
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	TCCR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	70 kDa
Manufacturer - Research Area	Apoptosis
Background	TCCR Antibody: Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.
By Type	Apoptosis
Badges	Trial Size
Modifications	None
Protein Gi #	4759328
Purification	TCCR Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1306-0.1mg
Positive Control 2	PRS-10-901-4um
Positive Control 3	PRS-17-003-1pack
Concentration	1 mg/ml
Buffer	TCCR Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	TCCR antibody can be used for detection of TCCR by Western blot at 1 μ g/mL. An approximately 70 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 10 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Homology	Predicted species reactivity based on immunogen sequence: Mouse: (87%)
Immunogen	TCCR antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human TCCR precursor. The immunogen is located within the first 50 amino acids of TCCR.
Clonality	Polyclonal
NCBI Official Name	interleukin 27 receptor, alpha
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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