IL-22 Receptor Antibody

Blue Ice

Predicted: 63 kDa
Observed: 65 kDa

IL-22 Receptor Antibody: A novel cytokine, designated IL-TIF for IL-10 related T cell-derived inducible factor and IL-22, was recently identified. The receptor for IL-22 (IL-22R, also termed CRF2-9 and IL-TIF-R1 chain) is a new member of the class II cytokine receptor family. IL-22R forms a complex with IL-10 receptor beta chain and mediates IL-22 signaling. IL-22 and its receptor activate JAK-STAT signaling pathway. IL22R is expressed in normal liver and kidney and their cell lines HepG2 and TK-10. A soluble form of IL-22 receptor, also termed IL-22 binding protein (IL-22BP) and IL-22 receptor-alpha 2 (IL-22RA2), was identified very recently. IL-22BP prevents binding of IL-22 to the functional cell surface IL-22R complex and neutralizes IL-22 activity. LPS induces IL-22 expression, which indicates the role of IL-22 in inflammatory response.

Trial Size

10719607

Cat. No. 1211 - HepG2 Cell Lysate

1 mg/mL

IL-22 receptor antibody can be used for detection of IL-22 receptor by Western blot at 0.5-1 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL and immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 10 μ g/mL.               
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples; Immunocytochemistry in human samples and Immunofluorescence in human and rat samples. All other applications and species not yet tested.

IL-22 receptor antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human IL-22 receptor precursor.

The immunogen is located within the first 50 amino acids of IL-22 Receptor.

interleukin 22 receptor, alpha 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.