Livin Antibody

Blue Ice

33 kDa

Livin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel member in the IAP protein family was recently identified and designated Livin and KIAP for kidney IAP. Livin/XIAP contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin-alpha and Livin-beta. Transfection of Livin in cells resulted in protection from apoptosis induced by FADD, BAX, RIP, RIP3 and DR6. Livin has direct interaction with several caspases including caspase-3, -7, and -9. Livin inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP. The two isoforms of Livin appear to have different functions and tissue distributions.

Trial Size

11545910

PRS-1207-0.1mg

PRS-11-801-4um

Livin Antibody is supplied in PBS containing 0.02% sodium azide.

A lower but much weaker band at 30 kDa was detected in Raji cell lysate, which may represent the short form of Livin.

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.