PARC Antibody

Primary Antibodies

PARC antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

PARC Antibody: The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.

Trial Size

24307991

PRS-1224-0.1mg

PARC Antibody is supplied in PBS containing 0.02% sodium azide.

PARC antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PARC.

The immunogen is located within the last 50 amino acids of PARC.

cullin 9

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.