Caspase-12 Antibody (Small)

Blue Ice

Predicted: 46 kDa (uncleaved)
Observed: 38 kDa

Caspase-12 Antibody: (Small)Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP). Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

Trial Size

2094806

PRS-1404-0.1mg

PRS-10-201-4um

Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide. (Small)

Predicted species reactivity based on immunogen sequence: Bovine: (93%)

Polyclonal

Mus musculus

Optimal dilutions for each application to be determined by the researcher.