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ACE2 Antibody

ACE2 Antibody

Item no.	PRS-3217-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Quantity options	0.02 mg 0.1 mg
Category	Oncology Neuroscience Aging & Neurological Disorders Neural Signaling Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Testicular & Prostate Cancer
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Donoghue et al. Circ. Res. 2000;87:1-9. Tipnis et al. J Biol. Chem. 2000;275:33238-43. Li et al. Nature 2003;426:450-4. Lu et al. The Lancet 2020 (published online). Crackower et al. Nature 2002;417:822-8. Wei, et al.Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection. Cell. 2020 Oct 20;S0092-8674(20)31392-1. doi: 10.1016/j.cell.2020.10.028.PMID: 33147444
NCBI	ACE2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ACE2 Antibody: ACEH,Angiotensin-converting enzyme 2,ACE-related carboxypeptidase,ACEH,SARS-CoV receptor,SARS-CoV-2 receptor
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	ACE2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	Predicted: 93kD Observed: 130 kD (7 N-linked glycosylation)
Manufacturer - Research Area	Infectious Disease
Background	ACE2 Antibody: Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. Homology modeling shows 2019-nCoV has a similar receptor-binding domain structure as SARS-CoV, which suggests COVID-19 (2019-nCoV) may use ACE2 as a receptor in humans for infection. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
By Type	Infectious Disease
Badges	Trial Size, Most Images
Modifications	None
Protein Gi #	11225609
Purification	ACE2 Antibody is affinity chromatography purified via peptide column.
Isoforms	Human ACE2 has 2 isoforms, including isoform 1 (805aa, 93kD) and isoform 2 (555aa, 64kD). Mouse ACE2 also has 2 isoforms, including isoform 1 (805aa, 92kD) and isoform 2 (353aa, 40kD). Rat ACE2 has one isoform (805aa, 93kD). 3215 can detect human, mouse and rat.
Validation	Independent Antibody Validation in Cell lines (Figure 1) shows similar ACE2 expression profile in human cell lines detected by three independent anti-ACE2 antibodies that recognize different epitopes, 3215 against central domain, 3217 against C-terminus domain and 3227 against N-terminus domain. ACE2 proteins are detected in the most tested tissues at different expression levels by three independent antibodies.
Positive Control 1	PRS-1305-0.1mg
Positive Control 2	PRS-10-401-4um
Positive Control 3	PRS-1306-0.1mg
Positive Control 4	PRS-1313-0.1mg
Concentration	1 mg/mL
Buffer	ACE2 Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	WB: 1-2 μ g/mL; IHC: 2 μ g/mL; IF: 10 μ g/mL. Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human samples; Immunofluorescence in human, mouse, and rat samples. All other applications and species not yet tested.
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (88%)
Manufacturer - Specificity	Anti-ACE2 has no cross response to ACE1.
Immunogen	Anti-ACE2 antibody (3217) was raised against a peptide corresponding to 18 amino acids near the carboxy terminus of human ACE2. The immunogen is located within the last 50 amino acids of ACE2.
Clonality	Polyclonal
NCBI Official Name	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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