MD-2 Antibody

Blue Ice

Predicted: 19kD
Observed: 26 kD (Post-modification: 2 N-linked glycosylations)

MD-2 Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.

Trial Size, Most Images

223555998

Human MD-2 has 2 isoforms, including isoform 1 (160aa, 18kD) and isoform 2 (130aa, 15kD). Mouse MD-2 has one isoform (160aa, 18kD) and Rat MD-2 also has one isoform (160aa, 18kD). 3289 can detect human, mouse and rat.

PRS-1406-0.1mg

PRS-10-901-4um

MD-2 Antibody is supplied in PBS containing 0.02% sodium azide.

Anti-MD-2 antibody (3289) was raised against a peptide corresponding to 13 amino acids near the center of human MD-2.

The immunogen is located within the last 50 amino acids of MD-2.

lymphocyte antigen 96

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.