RIPK1 Antibody

Blue Ice

Predicted: 74 kDa

RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell's decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.

Trial Size

57242761

1 mg/mL

RIPK1 antibody can be used for detection of RIP1 by immunohistochemistry at 5 - 10 μ g/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

RIPK1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human RIP1.

The immunogen is located within amino acids 600 - 650 of RIPK1.

receptor (TNFRSF)-interacting serine-threonine kinase 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.