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DRAM Antibody

DRAM Antibody

Item no.	PRS-33-062-100ug
Manufacturer	ProSci
Amount	100 ug
Category	Neuroscience Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Neural Development Antibodies Obesity Western Blot Lipid & Fatty Acid Transport Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
NCBI	DRAM
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DRAM Antibody: DRAM,DRAM,DNA damage-regulated autophagy modulator protein 1,Damage-regulated autophagy modulator
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.
Manufacturer - Research Area	Apoptosis, Autophagy, Cancer
Background	Autophagy is the mechanism by which lysosomes degrade unneeded or dysfunctional cellular components. p53 is a tumor suppressor protein that modulates autophagy and apoptosis. DRAM, or damage regulated autophagy modulator, is a lysosomal protein and effector of p53-mediated cell death. Many tumors show decreased DRAM expression and siRNA knockdown resulted in reduced cell death (Crighton et al, 2006).
By Type	Apoptosis, Autophagy, Cancer
Modifications	None
Purification	Protein A affinity chromatography
Concentration	0.5 mg/mL
Buffer	PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Application Note	Western blot: 4-8 ug/ml Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
Immunogen	A recombinant protein fragment from the N-terminal region of human DRAM was used as the immunogen for this antibody.
Clonality	Polyclonal
NCBI Official Name	damage-regulated autophagy modulator
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 12/4/2025

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