BTK Antibody

Blue Ice

Predicted: 76 kDa
Observed: 79 kDa

BTK Antibody: Bruton's tyrosine kinase (BTK) was initially identified as a member of the src family for protein-tyrosine kinases that was involved in X-linked agamma-globulinaemia, and has since been shown to involved in a number of signaling pathways in hemapoietic lineage. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.

Trial Size

547759

PRS-1215-0.1mg

1 mg/mL

BTK antibody can be used for the detection of BTK by Western blot at 0.5 to 2 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL and immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 10 μ g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Multiple isoforms of BTK are known to exist.

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.