GRP94 Antibody [SRPR90b]

Item no.	PRS-34-004-100ug
Manufacturer	ProSci
Amount	100 ug
Category	Oncology Neuroscience Neuroinflammation Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Neural Adhesion Molecules Antibodies By Cell Type Blastoma Carcinoma Hematology Myeloma Sarcoma Cell Biology Cell Movement Cell Adhesion Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies By Organ Lung Cancer
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IF, IHC-P
Clone	SRPR90b
Specific against	Human (Homo sapiens)
Host	Rat
Isotype	IgG2a Kappa
Conjugate/Tag	Unconjugated
NCBI	HSP90B1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Endoplasmin,94 kDa glucose-regulated protein,GRP-94,Heat shock protein 90 kDa beta member 1,Tumor rejection antigen 1,gp96 homolog,HSP90B1,GRP94,TRA1
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Manufacturer - Research Area	Cancer, Obesity, Signal Transduction
Background	Heat shock protein 90kDa beta member 1, known also as endoplasmin, gp96, grp94 and ERp99, is an HSP90 paralogue that is found in the endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. [Wiki]
By Type	Cancer, Obesity, Signal Transduction
Modifications	None
Purification	Protein G affinity chromatography
Concentration	0.2 mg/mL
Buffer	PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Application Note	Western blot: 1-2 ug/ml Immunofluorescence: 1-2 ug/ml Immunohistology (FFPE): 1-2 ug/ml for 30 min at RT (1) Prediluted format: incubate for 30 min at RT (2) Titering of the GRP94 antibody may be required for optimal performance. 1. FFPE testing requires sections to be boiled in pH6 10mM citrate buffer for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining. 2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Immunogen	Recombinant full-length human HSP90B1 protein was used as the immunogen for the GRP94 antibody.
Clonality	Monoclonal
NCBI Official Name	heat shock protein 90kDa beta (Grp94), member 1
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 11/6/2025

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