PTEN Antibody

Blue Ice

Predicted: 44, 63 kDa
Observed: 46 kDa

PTEN Antibody: PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a dual-specificity phosphatase (with both protein and lipid phosphatase activity) first identified as a tumor suppressor gene. PTEN indirectly activates the AKT/PI3K pathway, an important signaling pathway for cell growth and proliferation by keeping levels of the second messenger PIP3 low, thereby preventing phosphoinositide-dependent kinase-1 (PDK-1) from phosphorylating and activating AKT. Expression of wild-type PTEN causes growth arrest in many cancer cell lines, but expression of a PTEN protein containing a mutation that blocks its lipid phosphatase activity failed to suppress growth of glioma cell lines suggesting that the tumor suppressive effect of PTEN is mediated solely by its lipid phosphatase activity. Other activities include the inhibition of insulin stimulated MAPK activation by blocking the insulin-receptor substrate (IRS)-1 phosphorylation and assembly of the IRS-1/Grb2/Sos complex.

Trial Size

42560209

PRS-1286-0.1mg

PRS-17-206-1pack

PTEN Antibody is supplied in PBS containing 0.02% sodium azide.

PTEN antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PTEN.

The immunogen is located within the first 50 amino acids of PTEN.

phosphatase and tensin homolog

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.