TLR5 Antibody

blue ice or room temperature

Predicted: 94 kDa
Observed: 94 kDa

TLR5 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-κ B, leading to the activation of TNF-α and other cytokines. A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires'disease and demonstrates the importance of TLR5 in the innate immune response.

TLR5 Antibody is affinity chromatography purified via peptide column.

1 mg/ml

TLR5 antibody was raised against a peptide corresponding to 16 amino acids near the center of human TLR5.

The immunogen is located within amino acids 450 - 500 of TLR5.

toll-like receptor 5

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.