BAP31 Antibody

Blue Ice

Predicted: 28kD
Observed: 28kD

BAP31 Antibody: Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. It may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopicially, is also a potent inducer cell death.

Trial Size, IAV

32171186

Human BAP31 has 2 isoforms, including isoform 1 (246aa, 28kD) and isoform 2 (313aa, 34.8kD). Mouse BAP31 has one isoform (245aa, 28kD) and Rat BAP31 also has one isoform (245aa, 28kD). 3665 can detect human, mouse and rat.

PRS-1462-0.1mg

PRS-1282-0.1mg

BAP31 Antibody is supplied in PBS containing 0.02% sodium azide.

Anti-BAP31 antibody (3665) was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human BAP31.

The immunogen is located within the last 50 amino acids of BAP31.

B-cell receptor-associated protein 31

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.