BMI-1 Antibody

Primary Antibodies

BMI-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

BMI-1 Antibody: The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas. BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence. Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells, suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.

Trial Size

22258801

PRS-1204-0.1mg

1 mg/mL

BMI-1 antibody can be used for detection of BMI-1 by Western blot at 0.5 to 2 μ g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

BMI-1 antibody was raised against a peptide corresponding to 15 amino acids near the center of human BMI-1.

The immunogen is located within amino acids 140 - 190 of BMI-1.

BMI1 polycomb ring finger oncogene

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.