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PARL Antibody

PARL Antibody

Manufacturer	ProSci
Category	Metabolism Diabetes Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies
Type	Antibody Primary
Specific against	Human, Mouse, Rat, Chicken
Format	Liquid
Applications	WB, IHC, ELISA
Amount	0.1 mg
Host	Rabbit
Item no.	PRS-39-872-0.1mg
eClass 6.1	32160702
eClass 9.0	32160702
Available
Shipping	Dry Ice
By Research Area	Neuroscience, Apoptosis
Immunogen	Synthetic peptide to the C-terminus.
Applications	ELISA, Western (immuno) blotting, Immunostaining (in testing)
Purification	Affinity Purified
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Disclaimer	This product is for research use only.
Modifications	None
Ncbi Official Symbol	PARL
Accession #	NP_001032728
Protein Gi #	143811433
Ncbi Gene Id #	55486
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	APP
Ncbi Official Full Name	presenilin associated, rhomboid-like
Ncbi Organism	Homo sapiens
Swissprot #	Q9H300
Background	PARL is a rhomboid protease which has been shown to be involved in mitochondrial remodeling. PARL has also been shown to have antiapoptotic activity and protects cells from mitochondrial-dependent apoptotic pathway.
Background References 1	Jeyaraju DV, Xu L, Letellier MC, Bandaru S, Zunino R, Berg EA, McBride HM, Pellegrini L., Phosphorylation and cleavage of presenilin-associated rhomboid-like protein (PARL) promotes changes in mitochondrial morphology., Proc Natl Acad Sci U S A. 2006 Dec 5; 103(49):18562-7.
Background References 2	Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B., Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling., Cell. 2006 Jul 14; 126(1):27-9.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 6/6/2024