Fn14 Antibody

Predicted: 62kD

Observed: 68kD

Fn14 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fn14 Antibody: TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.

Fn14 Antibody is affinity chromatography purified via peptide column.

PRS-1304-0.1mg

1 mg/ml

Fn14 antibody was raised against a human IgG1 Fc-tagged Fn14 protein.

tumor necrosis factor receptor superfamily, member 12A

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.