Comparison

Neurotrypsin Antibody

Item no. PRS-4105-0.02mg
Manufacturer ProSci
Amount 0.02 mg
Quantity options 0.02 mg 0.1 mg
Category
Type Antibody Polyclonal
Format Liquid
Applications WB, IF, ELISA, IHC-P
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
Citations Gschwend TP, Krueger SR, Kozlov SV, et al. Neurotrypsin, a novel multidomain serine protease expressed in the nervous system. Mol. Cell. Neurosci.1997; 9:207-19.
Molinari F, Rio M, Meskanaite V, et al. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science2002; 1779-81.
Mitsui S, Yamaguchi N, Osako Y, et al. Enzymatic properties and localization of motopsin (PRSS12), a protease who absence causes mental retardation. Brain Res.2007; 1136:1-12.
NCBI PRSS12
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Neurotrypsin Antibody: MRT1, BSSP3, BSSP-3, Neurotrypsin, Leydin
Available
Manufacturer - Applications
Neurotrypsin antibody can be used for detection of neurotrypsin by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Shipping Temperature
blue ice or room temperature
Storage Conditions
Neurotrypsin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
Predicted: 96 kDa
Observed: 96 kDa
Manufacturer - Research Area
Neuroscience
Background
Neurotrypsin Antibody: Neurotrypsin is a central nervous system-expressed serine protease whose truncation or absence causes nonsyndromic mental retardation. It is most prominently expressed in structures that are involved in the processing and storage of learned behavior and memory, such as the cerebral cortex, the hippocampus, and amygdala. Evidence suggests that neurotrypsin has multiple functions, including axonal outgrowth, maintaining neuronal plasticity, and arranging the perineuronal environment, partly in coordination with other proteases including tissue plasminogen activator. At least two isoforms of neurotrypsin are known to exist.
Protein Gi #
2661424
Purification
Neurotrypsin Antibody is affinity chromatography purified via peptide column.
Positive Control 1
Positive Control 2
Concentration
1 mg/ml
Buffer
Neurotrypsin Antibody is supplied in PBS containing 0.02% sodium azide.
Immunogen
Neurotrypsin antibody was raised against a 23 amino acid synthetic peptide from near the amino terminus of human neurotrypsin.

The immunogen is located within amino acids 110 - 160 of Neurotrypsin.
Clonality
Polyclonal
NCBI Official Name
protease, serine, 12 (neurotrypsin, motopsin)
NCBI Organism
Homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 0.02 mg
Available: In stock
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