IFN-beta Antibody

Blue Ice

Predicted: 22kD
Observed: 22kD.

IFN-beta Antibody: Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

Trial Size, IAV

184623

Human IFN-beta has one (187aa, 22kD). Mouse IFN-beta has one isoform (182aa, 22kD) and Rat IFN-beta also has one isoform (184aa, 22kD). 4243 can detect human isoform, and possibly detect mouse and rat.

PRS-1288-0.1mg

PRS-10-201-4um

IFN-beta Antibody is supplied in PBS containing 0.02% sodium azide.

Anti-IFN-beta antibody (4243) was raised against a peptide corresponding to 17 amino acids near the center of human IFN-beta.

The immunogen is located within amino acids 110-160 of IFN-beta.

interferon, beta 1, fibroblast

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.