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Parkin (phospho Ser101) Antibody

Parkin (phospho Ser101) Antibody

Item no.	PRS-50-247-0.1mL
Manufacturer	ProSci
Amount	0.1 mL
Category	Neuroscience Neuroinflammation Neural Mitochondrial Function Protein Aggregation, Clearance & Misfolding Antibodies Cell Biology Cell Status Western Blot Autophagy Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	WB
Specific against	Human (Homo sapiens), Cattle (Bovine)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Jenner P, Dexter DT, Sian J, Schapira AH, Marsden CD (1992) Oxidative stress as a cause of nigral cell death in Parkinson’s disease and incidental Lewy body disease. Ann Neurol. 32 Suppl: S82-7. Yamamoto A, Friedlein A, Imai Y, Takahashi R, Kahle PJ, Haass C (2005) Parkin phosphorylation and modulation of its E# ubiquitin ligase activity. J Biol chem. 280(5):3390-9
NCBI	PARK2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Parkin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year.
Molecular Weight	52
Manufacturer - Research Area	Phospho-Specific
Background	Parkin is an E3 ligase in the ubiquitin-proteasome system. Hereditary Parkinson’s disease is most commonly caused by mutations in the parkin gene and is characterized by the progressive loss of dopaminergic neurons and the presence of Lewy bodies in the substania nigra (Jenner aet al., 1992). Recent evidence suggests that phosphorylation of parkin at Ser101 may have an important regulatory role on its E3 ubiquitin ligase activity (Yamamoto et al., 2005).
By Type	Phospho-Specific
Modifications	Phospho-Specific
Protein Gi #	116242725
Purification	Affinity Purified
Concentration	batch dependent
Application Note	The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will react with bovine and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Immunogen	Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser101 of human parkin.
Clonality	Polyclonal
NCBI Official Name	parkin RBR E3 ubiquitin protein ligase
NCBI Organism	Homo sapiens
Disclaimer	This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mL

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Delivery expected until 11/6/2025

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