Beta III Tubulin Antibody [AA10]

Blue Ice

55

Tubulin is the major constituent of microtubules, existing as a heterodimer of the alpha and beta subunits. The beta III isoform of tubulin is found almost exclusively in neuronal processes of adult tissues and is therefore an excellent marker for neurons. Neuron specific, posttranslational modifications within the C-terminal domain of beta III tubulin have been shown to be developmentally regulated suggesting that they may serve to modulate the interaction of tubulin with microtubule associated proteins (Lee et al., 1990). Additionally, beta III tubulin has been found to be highly expressed in cancer cells such as small cell lung cancer, large cell neuroendocrine carcinoma and adenocarcinomas and is correlated with an increasing histological degree of malignancy (Katsetos et al., 2003)

None

Protein G purified

Specific for the ~55kDa beta III tubulin protein. This clone is similar to the monoclonal antibody Tuj1.

Monoclonal

Rattus norvegicus

Optimal dilutions for each application to be determined by the researcher.