CYP2D6 Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

blue ice or room temperature

56 kDa

This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and is known tometabolize as many as 20% of commonly prescribed drugs. Itssubstrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; andamitryptiline, an anti-depressant. The gene is highly polymorphicin the population; certain alleles result in the poor metabolizerphenotype, characterized by a decreased ability to metabolize theenzyme's substrates. The gene is located near two cytochrome P450pseudogenes on chromosome 22q13.1. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This CYP2D6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6.

Cytochrome P450 2D6

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.