CYP2D6 Antibody

Primary Antibodies

Blue Ice

56 kDa

This gene encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum and is known to
metabolize as many as 20% of commonly prescribed drugs. Its
substrates include debrisoquine, an adrenergic-blocking drug;
sparteine and propafenone, both anti-arrythmic drugs; and
amitryptiline, an anti-depressant. The gene is highly polymorphic
in the population; certain alleles result in the poor metabolizer
phenotype, characterized by a decreased ability to metabolize the
enzyme's substrates. The gene is located near two cytochrome P450
pseudogenes on chromosome 22q13.1. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Rat

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.