SIRT6 Antibody

SIRT6 antibody can be used for detection of SIRT6 by Western blot at 0.5 - 1 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

SIRT6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

SIRT6 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT6 is a histone H3 lysine 9 deacetylase and is thought to stabilize the DNA-dependent protein kinase at double-stranded DNA breaks and may have a role in the process of mammalian aging.

SIRT6 Antibody is affinity chromatography purified via peptide column.

1 mg/ml

SIRT6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SIRT6.

The immunogen is located within the last 50 amino acids of SIRT6.

sirtuin 6

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.