SEMA4A Antibody

Primary Antibodies

Blue Ice

84 kDa

This gene encodes a member of the semaphorin family of
soluble and transmembrane proteins. Semaphorins are involved in
numerous functions, including axon guidance, morphogenesis,
carcinogenesis, and immunomodulation. The encoded protein is a
single-pass type I membrane protein containing an
immunoglobulin-like C2-type domain, a PSI domain and a sema domain.
It inhibits axonal extension by providing local signals to specify
territories inaccessible for growing axons. It is an activator of
T-cell-mediated immunity and suppresses vascular endothelial growth
factor (VEGF)-mediated endothelial cell migration and proliferation
in vitro and angiogenesis in vivo. Mutations in this gene are
associated with retinal degenerative diseases including retinitis
pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10).
Multiple alternatively spliced transcript variants encoding
different isoforms have been identified.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This SEMA4A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the N-terminal region of human SEMA4A.

Semaphorin-4A

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.