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NOTCH3 Antibody

NOTCH3 Antibody

Item no.	PRS-62-184-400ul
Manufacturer	ProSci
Amount	400 ul
Category	Antibodies Immunohistochemistry Western Blot Immunofluorescence Cardiovascular Research Atherosclerosis Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, IHC-P
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Suwanwela, N., et al.,Med Assoc Thai 86(2):178-182 (2003). Ahearn, E.P., et al., Am. J. Med. Genet. 114(6):652-658 (2002). Bellavia, D., et al., Proc. Natl. Acad. Sci. U.S.A. 99(6):3788-3793 (2002). Ito, D., et al., J. Neurol. Neurosurg. Psychiatr. 72(3):382-384 (2002). Joutel, A., et al., Lancet 350(9090):1511-1515 (1997).
NCBI	NOTCH3
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Neurogenic locus notch homolog protein 3,Notch 3,Notch 3 extracellular truncation,Notch 3 intracellular domain,NOTCH3
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Isotype	Rabbit Ig
Shipping Temperature	Blue Ice
Storage Conditions	Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	244 kDa
Manufacturer - Research Area	Neuroscience, Signal Transduction
Background	NOTCH3 is the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
By Type	Neuroscience, Signal Transduction
Modifications	None
Protein Gi #	322510053
Purification	This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration	batch dependent
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Application Note	For WB starting dilution is: 1:1000 For IF starting dilution is: 1:10~50 For IHC-P starting dilution is: 1:50~100
Homology	Predicted species reactivity based on immunogen sequence: Human
Immunogen	This NOTCH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.
Clonality	Polyclonal
NCBI Official Name	Neurogenic locus notch homolog protein 3
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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