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Prucalopride (succinate)

Prucalopride (succinate)

Item no.	HY-12694-1g
Manufacturer	MedChem Express
CASRN	179474-85-2
Amount	1 g
Quantity options	100 mg 10 mM/1 mL 10 mg 1 g 200 mg 500 mg 50 mg 5 mg
Specific against	other
Purity	99.95
Smiles	O=C(O)CCC(O)=O.O=C(C1=C(OCC2)C2=C(N)C(Cl)=C1)NC3CCN(CCCOC)CC3
Alias	R-108512
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	5-HT Receptor; Apoptosis; Autophagy
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	485.96
Product Description	Prucalopride succinate is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3][4].
Manufacturer - Research Area	Cancer; Metabolic Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : ≥ 20 mg/mL
Manufacturer - Pathway	Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Clinical information	Launched
Isoform	Apolipoprotein D

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HY-12694-1g-safety-datasheet.pdf