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BCL6 Antibody

BCL6 Antibody

Item no.	PRS-6985-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Quantity options	0.02 mg 0.1 mg
Category	Oncology Neuroscience Targets for Rodent Neurosciences Antibodies Western Blot ELISA Primary Antibodies By Organ Skin Cancer Heart & Blood Cancer Lymphatic System Cancer
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Ye BH, Chaganti S, Chang CC, et al. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma. EMBO J. 1995; 14:6209-17. Dent AL, Shaffer AL, Yu X, et al. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science1997; 276:589-92. Ye BH, Cattoretti G, Shen Q, et al. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat. Genet. 1997; 16:161-70. Hurtz C, Hatzi K, Cerchietti L, et al. BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia. J. Exp. Med. 2011; 208:2163-74.
NCBI	BCL6
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BCL6 Antibody: BCL5,LAZ3,BCL6A,ZNF51,ZBTB27,BCL5,B-cell lymphoma 6 protein,B-cell lymphoma 5 protein,BCL-6
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	BCL6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	78 kDa
Manufacturer - Research Area	Cancer, Cell Cycle
Background	BCL6 Antibody: BCL6 was first identified as a proto-oncogene in diffuse large B cell lymphoma. BCL6, a transcriptional repressor, plays an important role in lymphomagenesis. It binds Stat recognition-like DNA elements and is required for affinity maturation of mature B cells in germinal centers and Th1/Th2 differentiation, a process that critically depends on BCL6-mediated transcriptional repression of p53. BCL6 is a pharmacological target for eradication of leukemia-initiating cells in chronic myeloid leukemia (CML).
By Type	Cancer, Cell Cycle
Badges	Trial Size
Modifications	None
Protein Gi #	195927002
Purification	BCL6 Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1462-0.1mg
Concentration	1 mg/mL
Buffer	BCL6 Antibody is supplied in PBS containing 0.02% sodium azide.
Application Note	BCL6 antibody can be used for detection of BCL6 by Western blot at 1 μ g/mL. Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Manufacturer - Specificity	Three alternatively spliced transcript variants have been observed
Immunogen	BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of human BCL6. The immunogen is located within amino acids 370 - 420 of BCL6.
Clonality	Polyclonal
NCBI Official Name	B-cell CLL/lymphoma 6
NCBI Organism	homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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