PLA1A Antibody

blue ice or room temperature

50 kDa

PLA1A Antibody: PLA1A is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine (PS) in liposomes and can also hydrolyze PS in apoptotic cells and activate platelets where the resulting 2-acyl-lysophosphatidylserine acts as a lipid mediator for mast cells, T cells, and neural cells, suggesting that a major function of PLA1A may be the production of lysophospholipid mediators. PLA1A is upregulated in rat peripheral blood cells bearing long-term surviving cardiac allograft. PLA1A is also expressed in human THP-1-derived macrophages and this expression is upregulated in cells treated with lipopolysaccharide, a TLR4 ligand. This upregulation is inhibited with corticosteroids, which are often used at high dosages to suppress chronic allograft rejection.

PLA1A Antibody is affinity chromatography purified via peptide column.

PRS-10-401-4um

PLA1A Antibody is supplied in PBS containing 0.02% sodium azide.

PLA1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human PLA1A.

The immunogen is located within amino acids 380 - 430 of PLA1A.

phospholipase A1 member A

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.