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KREMEN1 Antibody

KREMEN1 Antibody

Item no.	PRS-7261-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Quantity options	0.02 mg 0.1 mg
Category	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Nakamura T, Aoki S, Kitajima K, et al. Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein. Biochim. Biophys. Acta. 2001; 1518:63-72. Mao B, Wu W, Davidson G, et al. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 2002; 417:664-7. Li J, Liu WM, Cao YJ, et al. Roles of Dickkopf-1 and its receptor Kremen1 during embryonic implantation in mice. Fertil. Steril. 2008; 90:1470-9. Wang K, Zhang Y, Li X, et al. Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism. J. Biol. Chem. 2008; 283:23371-5.
NCBI	KREMEN1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	KREMEN1 Antibody: KRM1, KREMEN, KRM1, Kremen protein 1, Dickkopf receptor
Available
Manufacturer - Applications	KREMEN1 antibody can be used for detection of KREMEN1 by Western blot at 0.125 - 0.25 μg/mL. Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	KREMEN1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	54 kDa
Manufacturer - Research Area	Signal Transduction
Background	KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.
Protein Gi #	24041012
Purification	KREMEN1 Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1468-0.1mg
Positive Control 2	PRS-11-801-4um
Concentration	1 mg/ml
Buffer	KREMEN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Immunogen	Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1. The immunogen is located within the last 50 amino acids of KREMEN1.
Clonality	Polyclonal
NCBI Official Name	kringle containing transmembrane protein 1
NCBI Organism	homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/4/2025

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