KREMEN2 Antibody

blue ice or room temperature

Predicted: 49kD
Observed: 49kD

KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.

KREMEN2 Antibody is affinity chromatography purified via peptide column.

PRS-1201-0.1mg

1 mg/ml

Anti-KREMEN2 antibody (7263) was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human KREMEN2.

The immunogen is located within amino acids 390-440 of KREMEN2.

kringle containing transmembrane protein 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.