N-RAS Antibody

Blue Ice

Predicted: 22 kDa
Observed: 22 kDa

N-RAS Antibody: Activating mutations and overexpression of classical Ras subfamily members (N-RAS, H-RAS, and K-RAS) have been widely investigated as key events in the development of human cancers. The N-RAS protein shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. N-RAS, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Trial Size

4505451

PRS-1202-0.1mg

N-RAS Antibody is supplied in PBS containing 0.02% sodium azide.

Predicted species reactivity based on immunogen sequence: Pig: (100%), Guinea pig: (93%), Chicken: (80%)

N-RAS antibody was raised against a 15 amino acid peptide near the carboxy terminus of human N-RAS.

The immunogen is located within the last 50 amino acids of N-RAS.

neuroblastoma RAS viral (v-ras) oncogene homolog

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.