TRIM33 Antibody

Blue Ice

Predicted: 70, 124 kDa
Observed: 70 kDa

TRIM33 Antibody: TRIM24 (TIF1alpha), TRIM28 (TIF1beta), and TRIM33 (TIF1gamma) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors (1-2). The structure of TRIM33 is similar to TRIM24 and TRIM28, exhibiting multiple domains (RING finger, coiled coil, B boxes, PHD/TTC, and bromodomain) (3). TRIM33 functions in cell differentiation and development, playing a role in differentiation of hematopoietic cells (3). It interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGF-beta (4). It acts as an E3 ubiquitin-protein ligase and promotes SMAD4 ubiquitination (5).

Trial Size

74027249

PRS-1304-0.1mg

1 mg/mL

TRIM33 antibody can be used for detection of TRIM33 by Western blot at 1 - 2 μ g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

TRIM33 antibody was raised against an 18 amino acid peptide near the center of human TRIM33.

The immunogen is located within amino acids 580 - 630 of TRIM33.

tripartite motif containing 33

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.