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ERAP2 Antibody

ERAP2 Antibody

Item no.	PRS-7469-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Quantity options	0.02 mg 0.1 mg
Category	Antibodies Cell Biology Cytoskeleton Western Blot ELISA Primary Antibodies small GTPases Ras Subfamily Rap Subfamily
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Saveanu L, Carroll O, Lindo V, et al. Concerted peptide trimming by EARP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat. Immunol. 2005; 6:689-97. Saric T, Chang SC, Hattori A, et al. An IFN-gamma induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat. Immunol. 2002; 3:1169-76. Cifaldi L, Romania P, Lorenzi S, et al. Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer. Int. J. Mol. Sci. 2012; 13:8338-52
NCBI	ERAP2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ERAP2 Antibody : LRAP, L-RAP, LRAP, Endoplasmic reticulum aminopeptidase 2, Leukocyte-derived arginine aminopeptidase
Available
Manufacturer - Applications	ERAP2 antibody can be used for detection of ERAP2 by Western blot at 1 - 2 μg/ml. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	ERAP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	Predicted: 106 kDa Observed: 120kDa
Manufacturer - Research Area	Innate Immunity
Background	The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2), a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1, 2). Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer (1). Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response (reviewed in 3).
Protein Gi #	11641261
Purification	ERAP2 Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1316-0.1mg
Concentration	1 mg/ml
Buffer	ERAP2 Antibody is supplied in PBS containing 0.02% sodium azide.
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (75%)
Immunogen	ERAP2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ERAP2. The immunogen is located within amino acids 110 - 160 of ERAP2 .
Clonality	Polyclonal
NCBI Official Name	endoplasmic reticulum aminopeptidase 2
NCBI Organism	homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.02 mg

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Delivery expected until 10/2/2025

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