MFN1 Antibody

Blue Ice

Predicted: 82 kDa
Observed: 83 kDa

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1, 2). MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development (3). When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane (4).

Trial Size

45269137

PRS-1202-0.1mg

1 mg/mL

MFN1 antibody can be used for detection of MFN1 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for Immunocytochemistry at 5 μ g/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

MFN1 antibody was raised against a 17 amino acid peptide near the amino terminus of human MFN1.

The immunogen is located within amino acids 20 - 70 of MFN1.

mitofusin 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.