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Comparison

MFN2 Antibody

Item no. PRS-7863-0.02mg
Manufacturer ProSci
Amount 0.02 mg
Quantity options 0.02 mg 0.1 mg
Category
Type Antibody Polyclonal
Format Liquid
Applications WB, IF, ELISA, IHC-P
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Conjugate/Tag Unconjugated
Citations Chen H, Detmer SA, Ewald AJ, et al. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 2003; 160:189-200.
Ishihara N, Eura Y, and Mihara K. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J. Cell Sci. 2004; 117:6535-46.
Bach D, Pich S, Soriano FX, et al. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J. Biol. Chem. 2003; 278:17190-7.
Renaldo F, Amati-Bonneau P, Slama A, et al. MFN2, a new gene responsible for mitochondrial DNA depletion. Brain 2012; 135:e223, 1-4.
NCBI MFN2
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias MFN2 Antibody: HSG,MARF,CMT2A,CPRP1,CMT2A2,KIAA0214,Mitofusin-2,Transmembrane GTPase MFN2
Shipping Condition Cool pack
Available
Manufacturer - Type
Primary Antibodies
Shipping Temperature
Blue Ice
Storage Conditions
MFN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Molecular Weight
Predicted: 83 kDa
Observed: 90 kDa
Manufacturer - Research Area
Obesity, Apoptosis
Background
Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1, 2). MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3, 4). Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5).
By Type
Obesity, Apoptosis
Badges
Trial Size
Modifications
None
Protein Gi #
7662004
Purification
MFN2 antibody is affinity chromatography purified via peptide column.
Positive Control 1
PRS-1303-0.1mg
Concentration
1 mg/mL
Buffer
MFN2 antibody is supplied in PBS containing 0.02% sodium azide.
Application Note
MFN2 antibody can be used for detection of MFN2 by Western blot at 1 - 2 μ g/ml. Antibody can also be used for Immunohistochemistry at 5 μ g/mL. For Immunoflorescence start at 20 μ g/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse and rat samples and Immunofluorescence in mouse and rat samples. All other applications and species not yet tested.
Manufacturer - Specificity
MFN2 antibody is human, mouse and rat reactive. At least three isoforms of MFN2 are known to exist. MFN2 antibody is predicted to not cross-react with MFN1.
Immunogen
MFN2 antibody was raised against a 17 amino acid peptide near the center of human MFN2.

The immunogen is located within amino acids 250 - 300 of MFN2.
Clonality
Polyclonal
NCBI Official Name
mitofusin 2
NCBI Organism
homo sapiens
Disclaimer
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note
Optimal dilutions for each application to be determined by the researcher.
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody
MFN2 Antibody

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.02 mg
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