JAK2 Antibody

Blue Ice

Predicted: 125 kDa
Observed: 125 kDa

JAK2 is a member of the JAK family of kinases that also include JAK1, JAK3, and TYK2 (1, 2). JAK kinases are activated following tyrosine phosphorylation of cytokine receptors after ligand binding. JAK2 activation promotes the recruitment and phosphorylation of STAT3 and STAT5. These transcription factors then translocate to the nucleus where they bind specific DNA promoter sequences resulting in the transcription of genes that regulate cell proliferation, differentiation, and apoptosis (3). Mice with a disrupted JAK2 gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis (4).

Trial Size

4826776

PRS-1212-0.1mg

JAK2 antibody is supplied in PBS containing 0.02% sodium azide.

Predicted species reactivity based on immunogen sequence: Pig: (100%), Chicken: (82%)

JAK2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human JAK2.

The immunogen is located within the last 50 amino acids of JAK2.

Janus kinase 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.