MALT1 Antibody

Blue Ice

Predicted: 91 kDa
Observed: 96 kDa

MALT1 was initially identified as a novel gene that was recurrently rearranged in t(11; 18)(q21; q21) mucosa-associated lymphoid tissue lymphomas along with the apoptosis inhibitor protein c-IAP2 (1). MALT1, along with the proteins CARMA1 and Bcl10 form an NF-kappaB-activating complex, termed the CBM signalsome, that acts downstream of lymphocyte antigen receptors as well as many other non-lymphoid cell-surface receptors that play a role in multiple cellular functions (2, 3). MALT1 has proteolytic activity, and this activity is critical for full NF-kappaB response in T cell activation (4).

Trial Size

5803078

PRS-1287-0.1mg

1 mg/mL

MALT1 antibody can be used for detection of MALT1 by Western blot at 1 - 2 μ g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

MALT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MALT1.

The immunogen is located within amino acids 630 - 680 of MALT1.

mucosa associated lymphoid tissue lymphoma translocation gene 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.