DIRAS3 Antibody

Blue Ice

Predicted: 25 kDa
Observed: 24 kDa

DIRAS3 is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with mono-allelic expression of the paternal allele, which is associated with growth suppression and down-regulation of cyclin D1 promoter activity and induction of p21 (WAF/CIP1). Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers (1). DIRAS3 has been shown to induce autophagy in human ovarian cancer cells by blocking PI3K signaling, inhibiting the mammalian target of rapamycin (TOR), upregulating ATG4, and colocalizing with LC3 in autophagosomes (2). DIRAS also interacts with C-RAF and downregulates mitogen-activated protein kinase kinases (MEK) to restrict cell migration (3).

Trial Size

4757772

PRS-1313-0.1mg

DIRAS3 antibody is supplied in PBS containing 0.02% sodium azide.

DIRAS3 antibody is human specific.

Polyclonal

homo sapiens

Optimal dilutions for each application to be determined by the researcher.