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PMEPA1 Antibody

PMEPA1 Antibody

Item no.	PRS-8261-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Quantity options	0.02 mg 0.1 mg
Category	Oncology Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Lung Cancer Testicular & Prostate Cancer Renal Cancer
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Xu LL, Shanmugam N, Segawa T, et al. A novel androgen-regulated gene, PMEPA1, located on chromosome 20q!3 exhibits high level expression in prostate. Genomics 2000; 66:257-63. Rae FK, Hooper JD, Nicol DL, et al. Characterization of a novel gene, STAG1/PMEPA1, upregulated in renal cell carcinoma and other solid tumors. Mol. Carcinog. 2001; 32:44-53. Watanabe Y, Itoh S, Goto T, et al. TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling. Mol. Cell 2010; 37:123-34. Vo Nguyen TT, Watanabe Y, Shiba A, et al. TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells. Cancer Sci. 2014; 105:334-41.
NCBI	PMEPA1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Prostate transmembrane protein androgen induced 1, STAG1, TMEPAI
Available
Manufacturer - Applications	PMEPA1 antibody can be used for detection of PMEPA1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	PMEPA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Molecular Weight	Predicted: 26, 28, 32 kDa Observed: 27 kDa
Manufacturer - Research Area	Cancer, Signal Transduction
Background	The prostate transmembrane protein, androgen induced 1 (PMEPA1) protein is a transmembrane protein that contains a Smad interacting motif (SIM) (1, 2). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins (3). Overexpression of this gene may play a role in multiple types of cancer (2, 4).
Protein Gi #	21361841
Purification	PMEPA1 antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1203-0.1mg
Concentration	1 mg/ml
Buffer	PMEPA1 antibody is supplied in PBS containing 0.02% sodium azide.
Immunogen	PMEPA1 antibody was raised against a 16 amino acid peptide near the center of human PMEPA1. The immunogen is located within amino acids 160 - 210 of PMEPA1.
Clonality	Polyclonal
NCBI Official Name	prostate transmembrane protein, androgen induced 1
NCBI Organism	homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 10/2/2025

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