DIS3L2 Antibody

blue ice or room temperature

Predicted: 97 kDa
Observed: 94 kDa

The exosome is involved in a multitude of cellular RNA processing and degradation events (1). DIS3, also known as exosome complex exonuclease RRP44, is a ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species (2). DIS3L2 is a paralog of DIS3, but unlike DIS3 is located in the cytoplasm (3). DIS3L2 defines a novel eukaryotic RNA degradation pathway and preferentially targets uridylated RNA (4). DIS3L2 mutations have also been associated with sporadic Wilms tumors (3).

DIS3L2 antibody is affinity chromatography purified via peptide column.

1 mg/ml

DIS3L2 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DIS3L2.

The immunogen is located within amino acids 720 - 770 of DIS3L2.

DIS3 like 3'-5' exoribonuclease 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.