IL-11 Antibody

blue ice or room temperature

Predicted: 20 kDa
Observed: 19 kDa

Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1). It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2). IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3). Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4).

IL-11 Antibody is affinity chromatography purified via peptide column.

PRS-17-001-1pack

IL-11 Antibody is supplied in PBS containing 0.02% sodium azide.

IL-11 antibody was raised against a 16 amino acid peptide from near the amino terminus of human IL-11.

The immunogen is located within amino acids 40 - 90 of IL-11.

interleukin 11

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.