DC-SIGN Antibody [8B6]

IgG1, k

DC-SIGN monoclonal antibody can be stored at -20˚ C, stable for one year.

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

Trial Size

46396012

PRS-1384-0.1mg

1 mg/mL

DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 mg/mL and in immunohistochemistry at 5 - 10 mg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Monoclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.