PD1 Antibody [8A4]

blue ice or room temperature

Predicted: 32 kDa
Observed: 38 kDa

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.

PD-1 Antibody is supplied as protein A purified IgG1.

PRS-1315-0.1mg

PRS-10-901-4um

PRS-17-010-1pack

PD-1 Antibody is supplied in PBS containing 0.02% sodium azide and 50% glycerol.

Monoclonal

Homo sapiens