Anti-Histone H2A Rabbit pAb

Primary Antibodies

Histone H2A

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

Histones are a family of basic proteins that form the core of the nucleosome – the fundamental structural unit of chromatin. In a single nucleosome, core histone proteins H2A, H2B, H3, and H4 form an octamer around which the DNA is tightly wrapped. Among these core histones, the H2A family shows the highest sequence divergence, especially in the C-terminal region, leading to variants including H2A.Z, H2A.X, MacroH2A, H2A.B etc. Histone H2A helps regulate chromatin structure and function through specialized variants and a wide variety of post-translational modifications (PTMs). These PTMs including acetylation, ubiquitination, methylation, phosphorylation, and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability and gene transcription.

Anti-Histone H2A Rabbit pAb detects endogenous levels of total histone H2A protein. It does not cross-react with other histone or non-histone proteins.

Unmodified

Polyclonal

Nucleus