Anti-Ubiquityl-Histone H2A (Lys119) Rabbit pAb

Primary Antibodies

Histone H2A

-20°C

Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Ubiquitination, a post-translational modification in which the ubiquitin is covalently attached to a substrate protein, occurs on histones H2A and H2B. Histone H2A is mono-ubiquitinated at Lys119 by the Polycomb Repressor Complex 1 (PRC1) and is critical for gene silencing, X chromosome inactivation, and cellular response to DNA damage. Histone H2A is also monoubiquitinated at Lys119 at sites of DNA damage.

Anti-Ubiquityl-Histone H2A (Lys119) Rabbit pAb detects histone H2A only when it is ubiquitinated at Lys119. This antibody has been shown to selectively recognize ubiquitinated H2A peptide at Lys119, but not the acetylated, crotonylated, or unmodified H2A peptide at Lys119 or Lys118.

Polyclonal