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Anti-Mouse/Rat CD126 (IL-6Ralpha) - Purified In vivo GOLD™ Functional Grade

Anti-Mouse/Rat CD126 (IL-6Ralpha) - Purified In vivo GOLD™ Functional Grade

Item no.	LEIN-I-1185-1.0mg
Manufacturer	Leinco Technologies
Amount	1 mg
Quantity options	0.5 mg 1 mg
Category	In Vivo Antibodies In Vivo Antibodies
Type	Antibody Monoclonal
Clone	15A7
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Purity	> 95% by SDS-PAGE and ≥ 95% monomer by analytical SEC
NCBI	16194
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping Condition	Cool pack
Available
Manufacturer - Applications	Quality Tested by Leinco FC The suggested concentration for this D7715A7 (15A7) antibody for staining cells in flow cytometry is ≤ 1.0 μg per 10⁶ cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. WB The suggested concentration for this D7715A7 (15A7) antibody for use in western blotting is 1-10 μg/ml.
Country of Origin	USA
Shipping Temperature	2 - 8°C
Storage Conditions	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Background	CD126 (IL-6Rα) is an 80 kD type I cytokine receptor α chain that is a member of the Ig superfamily that can form a heterodimer with IL-6Rβ chain to form the high affinity IL-6 receptor. The IL-6/IL-6R complex is a potent pleiotropic cytokine that mediates cell growth and differentiation and has significant involvement in immune response. Inadequate production of IL-6 and IL-6R are thought to play a part in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
Additional Reported Applications For Relevant Conjugates	N For specific conjugates of this clone, review literature for suggested application details.
PubMed	CD126
Manufacturer - Research Area	Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Manufacturer - Specificity	Clone D7715A7 (Clone 15A7) recognizes an epitope on mouse CD126.
RRID	AB_2737534
Concentration	≥ 5.0 mg/ml
Formulation	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Product Preparation	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Antigen Distribution	CD126 is expressed on activated T and B cells, monocytes, hepatocytes and plasma cells.
Endotoxin Level	≤ 1.0 EU/mg
Immunogen	OKT4 hybridoma cells
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-1185-1.0mg-safety-datasheet.pdf