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Anti-Mouse IFNgamma (Clone H22) - Purified In vivo GOLD™ Functional Grade Trial Size

Anti-Mouse IFNgamma (Clone H22) - Purified In vivo GOLD™ Functional Grade Trial Size

Item no.	LEIN-I-438-1.0mg-TrialSize
Manufacturer	Leinco Technologies
Amount	1 mg
Quantity options	1 mg 1 mg 100 mg 25 mg 5 mg 50 mg
Category	In Vivo Antibodies In Vivo Antibodies
Type	Antibody Monoclonal
Clone	H22
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Purity	> 95% by SDS-PAGE and ≥ 95% monomer by analytical SEC
Citations	1. Schreiber, RD. et al. (2017) Cancer Immunol Res. 5(2):106-117. 2. Diamond, MS. et al. (2017) J Virol. 91(22): e01419-17. 3. Schreiber, RD. et al. (2015) PLoS One.10(5):e0128636. 4. Goeddel, DV. et al. (1982) Nature 298: 859 5. Wilson, CB. et al. (2007) Adv. Immunol. 96: 41 6. Hume, DA. et al. (2004) J Leukoc Biol. 75: 163
NCBI	15978
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Shipping condition	Cool pack
Available
Manufacturer - Applications	Quality Tested by Leinco Western Blotting: For Western blotting, the suggested use of clone H22 antibody is 0.6 µg/ml., (See Image Above).
Manufacturer - Category	Purified in vivo Functional Grade>Gold Purified Bulk Antibodies\|Primary Monoclonal Antibodies>Growth Factors and Cytokines\|Purified in vivo Functional Grade
Manufacturer - Targets	Interferon Gamma
Country of Origin	USA
Shipping Temperature	Next Day 2-8°C
Storage Conditions	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product Description	Interferon-gamma (IFN-γ) or type II interferon is a dimerized soluble cytokine that is the only member of the type II class of interferons.4 It is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.5 IFN-γ has antiviral, immunoregulatory, and anti-tumour properties.6
Background	Interferon-gamma (IFN-γ) or type II interferon is a dimerized soluble cytokine that is the only member of the type II class of interferons.⁴ It is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.⁵ IFN-γ has antiviral, immunoregulatory, and anti-tumour properties.⁶
Additional Reported Applications For Relevant Conjugates	N For specific conjugates of this clone, review literature for suggested application details.
PubMed	Interferon Gamma
Ligand/Receptor	IFN-γRα (CDw119) dimerized with IFN-γRβ (AF-1)
Manufacturer - Specificity	Armenian Hamster Anti-Mouse Interferon-Gamma (IFN-γ) (Clone H22) recognizes an epitope on Mouse IFN-γ. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2737542
Concentration	≥ 5.0 mg/ml
Formulation	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Product Preparation	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Endotoxin Level	≤ 1.0 EU/mg
Immunogen	Purified Recombinant Mouse IFN-γ (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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LEIN-I-438-1.0mg-TrialSize-safety-datasheet.pdf