STAT3 Antibody (OAAH00030)

STAT3

770

6774

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Stat3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis.

This Aviva monoclonal antibody is produced by immunizing mice with a recombinant polypeptide (Aviva SEAL mAb technology) corresponding to urface multi-epitopes of human Stat3.