Anti-Retinoic Acid Receptor, Alpha-Isotype (OAPC00018)

RARA

ca.48kDa

5914

Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXR alpha, beta and gamma), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

Prepared from mouse ascites by ammonium sulfate precipitation followed affinity purification on a Protein G column.

Peptide corresponding to amino acid residues from the N-terminal region of human retinoic acid receptor, alpha -isotype.